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Together with the mechanistic platform in rodents, these translational findings lay the groundwork to create preventive individualized treatments targeting sex-specific changes in mitochondrial metabolism that may be subtle to early cognitive dysfunction of AD risk

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5 During the premonitory stage up to 3 days before headache, tiredness, mood changes, yawning, thirst, cravings, urinary frequency, light and sound sensitivity, and cranial autonomic symptoms may occur, while symptoms in the postdrome phase up to 48 hours post-headache include tiredness and difficulty concentrating

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