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Back in 2014, researchers behind a biological assay of AOD-9604 reported that the peptide had recently “‘generally recognized as safe’ (GRAS) status, conditional on publication of preexisting safety data, for its intended use in foods, drinks, and dietary supplements.”4 Per one review, encompassing all AOD-9604 human clinical trials to date: “In none of the studies did a withdrawal or serious adverse event occur related to intake of AOD9604 [ sic ].”7 Even in the Phase 2B trial, in which AOD-9604 failed to satisfy the primary and secondary endpoints, “the safety and tolerability of AOD9604 was excellent with no evidence of any difference from placebo [ sic ].”9 Recorded adverse events were almost entirely mild to moderate in severity: headaches, gastrointestinal distress, and other such common side effects
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Doses were inconsistent, side effects showed up more often than expected, and in some cases, the risks were serious enough to outweigh any potential benefits
