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Despite substantial weight loss, most obesity drugs such as Wegovy and Mounjaro do not meaningfully improve quality of life and few show cardiovascular benefits at one year, finds a new study in

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The analysis revealed 1,375 upregulated and 724 downregulated genes in methylglyoxal-treated cells, with gene ontology annotations pointing to defects in cytoplasmic and plasma membrane components and KEGG enrichment implicating type 1 diabetes, diabetic complications, and growth regulation