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It is therefore unsurprising that the LD 50 values for compounds 1 and 2 determined ex vivo have a similar discordance to that seen for PZQ when considering in vivo PK/PD: much like PZQ these compounds are schistosomicidal in vivo at sub LD 50 concentrations

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In a study of children whose parents had history of thyroid disease, Carey et al.(39) found a 24% prevalence of thyroid "abnormalities", including a prevalence of 6.9% abnormal thyroids, and 9.3% with positive TG Ab measured by hemagglutination assay (TGHA) and 7.8% positive MCHA assays