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LDN: The universal principle is “start low, go slow.” A typical ldn titration starts at 0.5 mg or 1.5 mg taken at bedtime, increasing by 1.5 mg every 2-4 weeks until a target dose of 4.5 mg is reached, or until positive effects are noted at a lower dose

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European Association for Cardio-thoracic Surgery/European Society of Thoracic Surgeons Joint Meeting, Lisbon, Portugal:Eur Assoc Cardiothorac Surg Abstract#7521, 2001