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4 Molecular mechanisms and signaling pathways 4.1 SIRT1: a molecular connection among intercommunication, neuroinflammation, and ferroptosis A conserved member of the sirtuin family, SIRT1 is a nicotinamide adenine dinucleotide (NAD + )-dependent class III histone deacetylase that regulates cellular metabolism, oxidative stress response, aging, mitochondrial function, and inflammation (Zhang and Kraus, 2010)