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While both types of folate increased Lactobacillus, Bifidobacterium, and Pediococcus, only the methylfolate increased the relative abundance of Firmicutes (by 4.49%).[ref] A 2025 study on gut microbiome composition in children with neurodiversity showed altered Firmicutes levels.[ref] The connection between methylfolate and folic acid feeding different bacteria may explain differing results in people with neurodiversity if part of the effect is in the gut microbiome

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In its most basic form, found in some bacterial Grxs, this fold consists of three α-helices surrounding a central core made up of a four-stranded β-sheet [3]