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The presence of α,β-unsaturated ketone moiety in [6]-shogaol contributes to its potent antioxidant and anti-inflammatory properties [593,598,599]

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and (e) show improvement over rapamycin in the treatment of a variety of in vivo models with mTORC1 hyperactivation due to TSC1/TSC2 loss, including syngeneic xenografts, native mouse genetic models, and human bladder cancer patient-derived xenografts