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Pulsatile GH Preservation Unlike exogenous recombinant GH (which is supraphysiological and suppresses endogenous pulsatility via negative feedback), tesamorelin preserves the physiological pulsatile GH architecture — confirmed in controlled healthy-subject studies (Clemmons DR et al., J Clin Endocrinol Metab 2011, PMID 20943777)

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doi: 10.1002/jcp.24217