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Plasma concentrations decline from roughly 200 ng/mL at age 20 to roughly 80 ng/mL by age 60 (Pickart and Margolina, 2018, published in Biomolecules)

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Figure 3 Throughout our in vitro experiments, we exposed activated ILC2s to a pharmacological concentration (250µM) of melatonin as has been shown previously to be maximally effective in driving phenotypic changes in T-cells without causing toxicity ( Figures 3F, G ), and was additionally required to produce maximal suppression of ILC2 activity ( Figures 3H, I )