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During the complex and tightly regulated oxidation processes such as glycolysis in the cytosol, and citric acid cycle and oxidative phosphorylation reactions in the mitochondria, electrons are used to power the synthesis of ATP, which then supports the high energy demands of tumor cells

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Figure 3 The integration of metabolomics into chronic disease research holds the potential to uncover novel biomarkers as therapeutic targets, thereby advancing personalized medicine and improving patient outcomes (Karczewski and Snyder, 2018)