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To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamate–cysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen

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Beyond the total mass, several quality variables sit outside the arithmetic: actual peptide purity (residual by-products, truncated sequences, counterion and water content that inflate apparent mass) and endotoxin or bioburden a sterility claim may not cover

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