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Baseline B12 deficiency: If a patient has lab-confirmed B12 deficiency (serum B12 below 200 pg/mL or elevated methylmalonic acid), the provider may prescribe a loading dose of B12 alone (1,000 mcg IM daily for 1 week, then weekly) before transitioning to combination MIC injections

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Table: Quick Comparison Feature IV: Therapy Oral Supplements Absorption Immediate Delayed Speed 2–4 weeks, 1–3 months Convenience requires appointments, At-home use Cost is High, more budget-friendly Choosing the right option depends on how quickly you want results, your comfort with clinical procedures, and your budget