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This involves sequential conjugation with glutathione (catalyzed by glutathione S-transferases, GSTs), followed by enzymatic processing to yield SFN-cysteine-glycine, SFN-cysteine, and ultimately SFN-N-acetylcysteine (SFN-NAC), which are the primary metabolites detected in plasma and urine (44, 45)

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This may explain the difference in the expression of ferroptotic markers between early (Aβ) and late (Aβ + p-tau) stages of AD