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The significant metabolites were then analysed using an unpaired Student’s t -tests and a false discovery rate by MetaboAnalyst 6.0 45 (listed in the supporting Extended Data Table 1)

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Methylcobalamin is unique to the functional relationship of methionine synthase (MS) components which include cobalamin, L-methylfolate, homocysteine, and in certain types of MS (but not all), and S-adenosylmethionine