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To investigate this hypothesis, researchers have studied the activities of thiamine-using enzymes in patients with and without Korsakoff ’s psychosis, arguing that variants of these enzymes may exist that could differ in their susceptibility to thiamine deficiency

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Endogenous antioxidants consist primarily of albumin, bilirubin, and enzymes involved in antioxidation, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione S-transferase (GST)