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Niacin or B3 Taking high-dose niacin supplements can result in skin-related allergic reactions, such as extreme facial flushing, also referred to as “niacin flush.” Flushing causes generalized itching and a burning sensation that is typically limited to the face and chest and lasts 20 to 30 minutes(1)

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Absorption through the oral mucosa bypasses the injection process entirely, though bioavailability and onset timing differ from subcutaneous administration