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In the last decades, guided tissue regeneration has been applied in many clinical trials for the treatment of various periodontal defects, such as infra-bony defects (23), furcation involvements (70, 86), and localized gingival recessions (118)

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Frequência:trimestral

Notably, addition of hemin or pyruvate, a source for NAD+ did not impact these growth phenotypes, suggesting that amelioration of heme defect or respiration inhibition is not sufficient to overcome anti-proliferative effects of mitochondrial GSH depletion (Extended Data Fig