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However, the resurgence of scientific interest and the increasing number of Food and Drug Administration FDA-approved trials signal a shift in the paradigm of the perception and application of these compounds [21,22]

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Mitochondrial sirtuin 3 (SIRT3) is a major modulator of mitochondrial metabolism and homeostasis, regulating UPR mt , mitochondrial biogenesis, mitophagy, fusion/fission, and antioxidant expression 98