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GLP-1 activation has several effects on your digestive system that directly cause GI symptoms: Delayed gastric emptying: Food stays in your stomach longer, causing fullness and sometimes nausea Altered intestinal motility: Changes in how quickly food moves through your intestines can cause either diarrhea or constipation Reduced appetite signals: Your brain receives signals to eat less, which changes your entire digestive rhythm Changes in bile acid secretion: This affects fat digestion and can contribute to loose stools Gut hormone changes: Multiple digestive hormones are affected, altering the normal digestive process Mounjaro Diarrhea: Causes, Duration, and Treatment Why Does Mounjaro Cause Diarrhea

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[DOI] [PubMed] [Google Scholar] 205.Okatani Y., Wakatsuki A., Enzan H., Miyahara Y