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The IM route became the standard for B12, and when compounding pharmacies began adding methionine, inositol, and choline to B12 injections in the 1990s, they kept the IM route

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Cagrilintide Phase 2 monotherapy (Lau et al., Lancet 2021) reported about 10.8% weight loss at 26 weeks at 4.5 mg