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An RCT by Maladkar et al

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Why this matters (and don’t underestimate it): • ~20% weight loss in non-diabetic obesity (REDEFINE-1) • 14–16% weight loss in T2D (REDEFINE-2) • Dual mechanism = appetite suppression + satiety reinforcement • Designed for long-term maintenance, not just short-term loss • Potentially better GI tolerability with flexible titration This isn’t “another GLP-1.” It’s a clear signal that amylin is emerging as a serious second pillar in next-gen obesity care