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A key issue here could be changes in NADP(H) redox status and the relatively low capacity of glutathione disulfide (GSSG)-reducing systems such as glutathione reductase (GR) compared with GSH-oxidizing mechanisms (discussed further in Noctor et al., 2010) THE IMPORTANCE OF MODIFICATIONS IN GLUTATHIONE AND ASCORBATE IN TRANSMITTING ROS SIGNALS Three properties mark out glutathione as a candidate transmitter of intracellular ROS signals: (1) glutathione is highly reduced under optimal conditions

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