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Under the ROS stimulation, the thin-sophisticated moiety (-SH) of cysteine residues is oxidized to form reversible intramolecular disulfide bonds (R-S-S-R) and sulfinyl groups (R-SOH), or irreversible sulfinic acids (R-SO 2 H) and sulfonic acids (R-SO 3 H) ( As we mentioned earlier, GPX7 does not contain domains bound to GSH, so it cannot participate in redox reactions with GSH as a substrate like other GPX family members

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233 Further, nanocurcumin formulation from Theravalues Corp., Japan was demonstrated to downregulate IL-6, hs-CRP, MDA, and upregulate IL-10, brain-derived neurotrophic factor (BDNF), and TAC in MetS patients

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