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ND, not detected a The limit of detection for dG monoadducts, dA monoadducts, and dG-dG crosslinks was ≈240, ≈75, and ≈60 atto mol, respectively

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To interrogate the potential effect of the lipidation on the Cagri-bound structures, we also determined structures of the CTR and AMY 1 R bound to a Cagri analogue lacking the N-terminal lipidation (CagriBB)