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The compound's mechanism of action centers on inducing an acute aerobic exercise genetic program through ERRΞ±-dependent activation of DDIT4 (DNA Damage Inducible Transcript 4), a key protein transiently expressed following aerobic exercise that orchestrates numerous physiological adaptations including increased oxidative fibers, enhanced fatty acid oxidation, and improved exercise endurance
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Up-regulation of EGR-1 and cyclin D1 A bit more technical: EGR-1 (Early Growth Response 1) and cyclin D1 are transcription factors, proteins that, in the cellβs nucleus, determine which genes are βswitched onβ