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This kinase cascade is part of the broader MAP kinase signaling network that regulates cell proliferation, differentiation, and stress response pathways

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Oxidative stress caused by a variety of agents and drug-resistant tumor cell lines are two conditions associated with increased cell GSH levels, GCL activity, GCLC mRNA levels and GCLC gene transcription (Mulcahy et al., 1994a

95% of all carnitine stores in the body are found in muscle tissue