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4 Immunometabolism as the link between steroid hormones and inflammation and immunity 4.1 Glucocorticoids As discussed, glucocorticoid receptor signaling promotes anti-inflammatory and immunosuppressive activities of innate immune cells, including macrophages and myeloid-derived suppressor cells
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HIF-1α can regulate the expression of VEGF gene under hypoxic stimulation (212), which is related to the adaptation of RA synovial membrane to the hypoxic microenvironment (211)