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Research suggests that adenosylcobalamin can support methylcobalamin's role in the methylation cycle better than the synthetic form of B12, cyanocobalamin, as it must be converted into adenosylcobalamin and methylcobalamin first, a process that may interfere with the cycle and make the methylation pathway less efficient for individuals with B12-related polymorphism

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Wrinkle reduction: Badenhorst et al