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Lysyl oxidase only works once copper is loaded onto it inside the cell, and GHK-Cu supplies that copper: a 2025 delivery study measured copper accumulating in the right compartment and lysyl oxidase activity rising to 1.78 times control.¹⁰ A second 2025 group found the same copper-handoff behavior from a different GHK-based molecule.¹¹ That is the chain the mechanism predicts, measured end to end — copper delivered, the cross-linking enzyme switched on, matrix built and locked together

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Single-cell RNA sequencing results show that disturbed MQC aggravates ferroptosis through excessive mitochondrial fission and autophagy