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We therefore manipulated components of the methionine cycle to either increase the expression of methionine adenosyltransferase (MAT2A), glycine N-methyltransferase (GNMT), or adenosyl-homocysteinase (AHCY) that favor homocysteine generation, or reduce the expression of the 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) enzyme that can convert homocysteine back to methionine (Figures 3A, 3B and S3A)

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Extracellular vesicles (EVs) are secreted by a variety of cells, including adipocytes (159), and increasing evidence suggests that they may mediate paracrine/endocrine effects (160, 161)