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GLP-1 receptor agonists Including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) — are peptide-based drugs that have completed full FDA review and carry approved indications for type 2 diabetes and obesity

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Inhibitory effect of hypoxic condition on acetylcholine release is partly due to the effect of adenosine released from the tissue