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Sci Rep (2020) 10 (1):16146

CC Upsell 2

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(1992, Biochem J) demonstrated that IGF-1 and its variants — including Long R3 IGF-1 — are anabolic in dexamethasone-treated rats, confirming the utility of IGF-1 LR3 in models of catabolic states and muscle wasting where native IGF-1 activity is suppressed by glucocorticoid-driven IGFBP upregulation