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Eventually, it was concluded that, on the one hand, DADS‐induced cytotoxicity was prevented by the H 2 S scavenger hydroxocobalamin, which also prevented cytochrome oxidase‐dependent mitochondrial respiration suggesting that H 2 S inhibition of cytochrome oxidase contributed to DADS hepatocyte cytotoxicity

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Figure 1 3 Mitochondrial dysfunction is strongly associated with impaired glucose and lipid metabolism in obesity and diabetes Prolonged overload by nutrient substrates causes mitochondrial dysfunction (49), which can occur in multiple ways, including mitochondrial swelling, smaller mitochondrial cristae, imbalanced mitochondrial dynamics, and abnormalities in the mitochondrial respiratory chain (50, 51)