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The molecule is not available in the human diet, making direct supplementation the only feasible route to restore levels.” CaAKG has been shown to slow the rate of age-related DNA methylation and reduce the inflammation caused by senescent cells: two major contributors to aging

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In tomato cell suspensions, upon xylanase perception, cells activate a protein kinase pathway required for NO formation and S -nitrosylation-dependent mechanisms which are involved in downstream signaling, leading to production of polyamine and ROS production (Lanteri et al., 2011)