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Tyrosine hydroxylase is involved in the synthesis of catecholamines, leading to heightened production of substances like dihydroxyphenylalanine (DOPA), norepinephrine, and dihydroxyphenylglycol (DHPG) ( Cholinergic anti-inflammatory pathways Neurotransmitters, specifically adenosine triphosphate (ATP) and acetylcholine (ACh), are responsible for mediating the activation or initiation of contractions in the urinary bladder’s smooth muscle through the engagement of purinergic and/or muscarinic receptors (Tsai et al., 2012)

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Der TAME-Trial soll hier wichtige Antworten liefern – allerdings kämpft die Studie seit Jahren mit Finanzierungs- und Anlaufschwierigkeiten und liegt inzwischen unter dem Dach von ARPA-H