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[12] Postulated effects of glutathione on pigmentation The role of glutathione as a skin-lightening agent was an accidental discovery when skin lightening was noticed as a side effect of large doses of glutathione

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Potential mechanisms for this loss of bone mineral density include changes in methionine levels with fasting and hormonal adaptations to fasting including increases in the counter-regulatory hormone cortisol and decreases in IGF-1 levels due to GH resistance (see section Growth Hormone Resistance and Hypogonadotropic Hypogonadism), which have negative effects on bone mass (93)